Profhilo®

Profhilo® is an injectable skin bio-remodelling treatment designed to improve skin quality, hydration, elasticity, and firmness without adding volume or altering facial contours. It represents a unique hyaluronic acid–based approach that works by stimulating the skin’s own regenerative processes rather than acting as a traditional filler.

Profhilo® is distinguished by its unique manufacturing process, which allows the product to remain in the tissue up to 30 times longer than conventional non-crosslinked hyaluronic acid products. With 64 mg of pure hyaluronic acid in 2 ml, Profhilo® is the highest-concentration hyaluronic acid product available worldwide and has received multiple international awards for its innovative and effective method.

The absence of chemical crosslinking agents such as BDDE ensures excellent biocompatibility, high tolerability, and a minimal risk profile. This unique composition also allows Profhilo® to be safely combined with other aesthetic treatments, including botulinum toxin.

 

What Makes Profhilo® Unique

  • Extremely high concentration of pure hyaluronic acid (64 mg / 2 ml)
  • Prolonged tissue residence time compared to standard HA products
  • No chemical crosslinking agents (e.g. BDDE)
  • Excellent safety and tolerability profile
  • Award-winning technology for skin bio-remodelling
  • Ideal for combination treatments such as botulinum toxin or other aesthetic procedures

 

Indications and Treatment Areas

Profhilo® is particularly suitable for:

  • Improving skin hydration and elasticity
  • Enhancing skin firmness and overall texture
  • Treating skin laxity and early signs of aging
  • Supporting skin quality in anti-aging and longevity-focused concepts

Common treatment areas include:

  • Face
  • Neck
  • Décolletage
  • Hands

Treatment Protocol

  • Typically performed as 2 treatment sessions
  • Sessions are spaced 4 weeks apart
  • Injected using specific bio-aesthetic injection points to allow even tissue diffusion
  • Treatment is performed in a medical outpatient setting

When Results Become Visible

  • Results develop gradually over approximately 4 to 6 weeks after the first treatment
  • Skin quality continues to improve as hydration, elasticity, and firmness increase
  • Optimal results are usually observed after completion of the second session

Results and Longevity

  • Noticeable improvement in skin hydration, smoothness, and firmness
  • Natural-looking skin rejuvenation without volumizing effects
  • The effects generally last 6 to 9 months, with some patients experiencing benefits for up to 12 months, depending on individual factors. Regular maintenance treatments can help preserve long-term results.

Pain, Downtime, and Safety

  • Minimally invasive treatment with little to no downtime
  • Mild redness, swelling, or small injection marks may occur temporarily
  • Generally well tolerated due to its high biocompatibility
  • Low risk of side effects when performed by experienced medical professionals

Combination Treatments

Profhilo® can be safely combined with:

  • Botulinum toxin for wrinkle reduction and muscle relaxation
  • Hyaluronic acid fillers for contouring and volume restoration
  • Other skin rejuvenation treatments to further enhance skin quality

Profhilo® is an ideal option for patients seeking natural skin rejuvenation, improved skin quality, and long-term anti-aging benefits without adding volume.

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